Depression and low mood are complex mental health conditions that can significantly impair an individual's quality of life.

While traditional treatments such as talking therapy and antidepressant medications are commonly prescribed, some individuals seek alternative or adjunctive therapies to manage their symptoms. In recent years, there has been growing interest in the potential therapeutic effects of medical cannabis in alleviating depression and low mood.

Understanding Depression and low mood:

Depression is a mood disorder characterised by persistent feelings of sadness, hopelessness, and loss of interest or pleasure in activities. Low mood, whilst not always indicative of clinical depression, can still have a significant impact on an individual's well-being and functioning. Both conditions can be influenced by various factors, including biological, psychological, and social.

The endocannabinoid system and mood regulation:

The endocannabinoid system (ECS) is a complex network of receptors, endocannabinoids (cannabinoids produced by the body), and enzymes involved in regulating various physiological processes, including mood. Research suggests that dysregulation of the endocannabinoid may contribute to mood disorders such as depression. Cannabinoids found in cannabis, including tetrahydrocannabinol (THC) and cannabidiol (CBD), interact with the endocannabinoid system and may aid mood regulation.

The potential therapeutic effects of cannabinoids:


Tetrahydrocannabinol, the primary psychoactive compound in cannabis, has been shown to produce euphoria and relaxation in some individuals. However, high doses of THC may exacerbate anxiety and paranoia, which can worsen symptoms of depression in susceptible individuals. Therefore, careful dosing and supervision are essential when using THC for mood management. At Cantourage Clinic, you will be prescribed and guided to ensure the medication you receive is well-suited for your needs and goals.


Cannabidiol, a non-psychoactive compound in cannabis, has drawn attention for its potential anxiolytic and antidepressant properties. Some studies suggest that CBD may modulate serotonin receptors in the brain, which are implicated in mood regulation. Additionally, CBD has been investigated for its anti-inflammatory and neuroprotective effects, which could potentially benefit individuals with mood disorders.

Other cannabinoids and terpenes:

Beyond THC and CBD, cannabis contains numerous other cannabinoids and terpenes that may contribute to its therapeutic effects. For example, beta-caryophyllene, a terpene found in cannabis, exhibits anti-anxiety and antidepressant properties by acting on the ECS. Research into these lesser-known compounds is still in its early stages but holds promise for future therapeutic developments.

Considerations and caveats:

While medical cannabis shows promise as a potential treatment for depression and low mood, several considerations should be kept in mind:

Individual responses:

Cannabis affects individuals differently, and what is effective for one person may not yield the same results for another. At Cantourage Clinic, our focus is on tailoring prescriptions and providing guidance to ensure that the medication you receive is optimally suited to meet your specific requirements.

Side effects:

Like any medication, medical cannabis may cause side effects, including dizziness, dry mouth and cognitive impairment. Understanding and managing these side effects is crucial for optimising treatment outcomes.

Legal and regulatory considerations:

Medical Cannabis has been legal in the UK since 2018, however there are legal considerations to consider, as there are protocols which need to be considered when travelling with medical cannabis. Patients should familiarise themselves with local laws and regulations before pursuing cannabis as a treatment option.

In conclusion, while the potential therapeutic benefits of medical cannabis for depression and low mood are promising, it's important to approach treatment with caution and guidance. At Cantourage Clinic, we understand the complexities of individual responses to cannabis based treatments and are committed to providing personalised care tailored to your unique needs and goals. Our team of healthcare professionals are dedicated to ensuring that you receive the support and guidance necessary to navigate your treatment journey effectively. If you're considering medical cannabis as an option for managing depression or low mood, we encourage you to start your journey with us by taking our FREE eligibility checker and booking in a consultation. 

About Cantourage Clinic Ltd

Cantourage Clinic is a CQC registered clinic, combining a team of qualified specialist physicians, nurses and educators with cannabis industry professionals; joining forces with the sole focus of providing care and excellence for patients wishing to explore cannabinoid therapies.

For more information on how Cantourage clinic could help, click here for more information.

Cantourage Clinic offer specialist consultations for the following conditions.

- Pain

- Psychiatry

- Neurology

- Gastroenterological

- Oncology

- Palliative Care


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