Cannabis as a medicine was used before the Christian era in Asia, mainly in India. The introduction of cannabis in the Western medicine occurred during the 19th century, reaching the climax in the last decade of that century, with the availability and usage of cannabis extracts or tinctures.
In the early 20th century, the Western medical use of cannabis significantly decreased largely due to difficulties to obtain consistent results from batches of plant material of different potencies.
In the 1960s, Professor. Raphael Mechoulam began his cannabinoid research ultimately discovering the chemical structure of cannabis (cannabinoids). The possibility of obtaining its pure constituents, isolating THC (tetrahydrocannabinol) resulted in a significant increase of scientific interest in the cannabis plant. Prof. Mechoulam studied the pharmacological, metabolical and clinical effects. The positive findings paved the way to important major new discoveries about cannabinoids, such as the identification of cannabinoid receptors and the endogenous cannabinoid (endocannabinoid) system in the brain.